ARPA-H
Overview
A U.S. government research funding agency within the Department of Health and Human Services (HHS) that supports transformative, high-risk, high-reward biomedical and health research. Modeled after the Defense Advanced Research Projects Agency (DARPA), it was established to accelerate breakthroughs in medicine and health that cannot be readily accomplished through traditional research or commercial activity. ARPA-H is disease-agnostic and funds projects using mechanisms like cooperative agreements and Other Transaction Authority (OTA) agreements, rather than providing dilutive capital. It operates as an independent entity within the National Institutes of Health (NIH).
Portfolio Companies
63
Website
arpa-h.govInvestments
| Company | Date | Stage | Lead |
|---|---|---|---|
| Seaport Therapeutics | Mar 2026 | Grant | Co-investor |
| Virtuoso Surgical, Inc. | Jan 2025 | Grant | Lead |
| Gameto | Oct 2024 | Grant | Lead |
| Cellino | Sep 2024 | Grant | Co-investor |
| Esperto Medical | Apr 2026 | Grant | Co-investor |
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Key People
Maryam Ziaei
Director of Technology Transfer and Transition (T3X)
Sector & Stage Mix
Industry, funding stage, and valuation band breakdowns.
FAQ
Where is ARPA-H based?
ARPA-H is headquartered in District of Columbia.
When was ARPA-H founded?
Founding year information for ARPA-H is not publicly available.
How many portfolio companies does ARPA-H have?
ARPA-H has 63 portfolio companies in Caplight's dataset.
What are some companies in ARPA-H's portfolio?
Portfolio companies visible on Caplight include Seaport Therapeutics, Virtuoso Surgical, Inc., Gameto, Cellino, Esperto Medical.
What was ARPA-H's most recent investment shown here?
ARPA-H's most recent investment in this portfolio sample was in Esperto Medical in 2026.
What sectors does ARPA-H focus on?
ARPA-H focuses on Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Frontier & Industrial Tech, FinTech, Cybersecurity, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Healthcare & Life Sciences, Cybersecurity, Cybersecurity, Healthcare & Life Sciences, Frontier & Industrial Tech, Healthcare & Life Sciences, Frontier & Industrial Tech, AI, Data & Cloud Infrastructure, AI, Data & Cloud Infrastructure, Enterprise Software, AI, Data & Cloud Infrastructure, Healthcare & Life Sciences, Healthcare & Life Sciences, Enterprise Software, AI, Data & Cloud Infrastructure, AI, Data & Cloud Infrastructure, Enterprise Software, AI, Data & Cloud Infrastructure, Enterprise Software, Frontier & Industrial Tech, Frontier & Industrial Tech, Frontier & Industrial Tech, AI, Data & Cloud Infrastructure, Enterprise Software, Frontier & Industrial Tech, Frontier & Industrial Tech, Frontier & Industrial Tech, Consumer & Commerce, Frontier & Industrial Tech, Frontier & Industrial Tech, Frontier & Industrial Tech, Frontier & Industrial Tech, AI, Data & Cloud Infrastructure, Enterprise Software, Healthcare & Life Sciences, Frontier & Industrial Tech, Frontier & Industrial Tech, Frontier & Industrial Tech, Frontier & Industrial Tech.
What company stages does ARPA-H focus on?
ARPA-H typically invests at the MultiStage stage.
What is ARPA-H's AUM?
ARPA-H's assets under management are estimated between $1.0B and $1.5B.